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Allergy diagnostics

Overview of laboratory services

Allergies are immune-mediated hypersensitivity reactions to foreign substances from the environment that are usually harmless. Around 30 million Germans suffer from allergies, such as hay fever, asthma, neurodermatitis, or food allergies. Chronic allergic disorders may significantly diminish quality of life. The steadily increasing number of people with allergies is probably an indication of decreasing immune tolerance and is often associated with lifestyle in industrialised countries. A diagnosis of the triggering allergens can provide useful help for effective therapy. Allergic reactions can manifest in different ways. The laboratory diagnostic spectrum includes the further investigation of type I, III and IV allergies and pseudoallergic reactions. 

Type I Allergy

IgE-mediated type I allergy is accompanied by mild to life-threatening symptoms. Allergen-specific IgE antibodies are formed after initial contact with the allergen and bind to the cell surface of histamine-rich cells, basophilic granulocytes or mast…

Type III allergy

Type III allergy is understood as an allergic immune complex reaction mediated by antibodies (IgG, IgA, IgM). Immune complexes of antibodies and antigens are formed after contact with an allergen. Special components of the complement system induce…

Type IV allergy

Potential sensitisation to metals, dental substances, or medications caused by an underlying mechanism of specific T cell activation and proliferation and results in a symptomatic type IV allergy (delayed hypersensitivity reaction) upon repeated…

Pseudo-allergies

Pseudo-allergic reactions are inflammatory reactions that are based on the release of inflammatory mediators from mast cells and basophilic granulocytes that is not mediated by IgE antibodies. Food colourings and additives, medicinal product…

Titanium Implant Intolerance

Although there are still many doctors who argue whether or not the body reacts negatively to titanium, there have been numerous reports published of aseptic titanium-associated inflammatory reactions in the past few years that have delayed or even…